Tuesday, April 8, 2025
| Registration |
| 08.00 am-09.00 am (GMT+1)
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| Welcome notes |
| 09.00 am-09.20 am (GMT+1)
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| Invited Talk |
| 09.20 am-09.50 am (GMT+1)
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| Chair: Rotem Sorek, Weizmann Institut of Science, Israel |
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1
09.20 am |
Phages : a totally unexpected and fascinating Renaissance
Pascale Cossart
Institut Pasteur, Paris, France
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| Nucleic acids and antiphage defense - Part 1 |
| 09.50 am-10.40 am (GMT+1)
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| Chair: Rotem Sorek, Weizmann Institut of Science, Israel |
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2
09.50 am |
Temperate phages enhance host fitness via RNA-guided flagellin regulation
Samuel Sternberg
Department of Biochemistry and Molecular Biophysics, Columbia University, New-York, United States
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3
10.20 am |
TIGR-Tas – A modular RNA-Guided Systems found in Prokaryotes and their Viruses
Guilhem Faure
Zhang lab, The Broad Institute of MIT and Harvard, Cambridge, United States
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| Coffee Break |
| 10.40 am-11.20 am (GMT+1)
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| Nucleic acids and antiphage defense - Part 2 |
| 11.20 am-12.40 pm (GMT+1)
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| Chair: Anne Chevallereau, CNRS, France |
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4
11.20 am |
Structure and Activation Mechanism of a Lamassu Phage Defence System
Stephan Gruber
Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland
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5
11.40 am |
Homopolymeric DNA synthesis by a defense-associated reverse transcriptase
Stephen Tang
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, United States
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6
12.00 pm |
Bacterial reverse transcriptase synthesizes long poly-A-rich single-stranded cDNA for anti-phage defense
Ning Jia
Southern University of Science and Technology, Shenzhen, China
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7
12.20 pm |
Retron Eco2 breaks tRNAs for anti-phage defense
Patrick Pausch
LSC-EMBL, Vilnius University, Vilnius, Lithuania
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| Lunch and Posters Session 1 - Part 1 |
| 12.40 pm-2.30 pm (GMT+1)
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| Diversity and conservation of antiviral immunity in bacteria and beyond |
| 2.30 pm-5.20 pm (GMT+1)
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| Chair: David Burstein, Tel Aviv University, Israel |
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8
2.30 pm |
How bacteria diversify their immune systems
Aude Bernheim
Molecular Diversity of Microbes Lab, Institut Pasteur, CNRS UMR3525, Université Paris-Cité, Paris, France
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9
3.00 pm |
DefensePredictor: A Machine Learning Model to Discover Novel Prokaryotic Immune Systems
Peter Deweirdt
Laub Lab, MIT, Cambridge, United States
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10
3.20 pm |
Integrons as biobanks of minimal defense systems
Eduardo Rocha
Institut Pasteur, Paris, France
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11
4.30 pm |
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins
Shai Zilberzwige Tal
The Broad Institute of MIT and Harvard, Cambridge, United States Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, United States
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12
4.50 pm |
Ancient origins of immune components in bacteria
Tanita Wein
Weizmann Institut of Science, Rehovot, Israel
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| Posters Session 1 - Part 2 |
| 5.20 pm-7.30 pm (GMT+1)
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| Welcome reception - Wine and Cheese |
| 7.30 pm-9.30 pm (GMT+1)
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Wednesday, April 9, 2025
| Welcome coffee |
| 08.30 am-09.00 am (GMT+1)
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| Nucleotides and antiphage defense - Part 1 |
| 09.00 am-10.20 am (GMT+1)
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| Chair: Jens Hör, Helmholtz Centre for Infection Research (HZI), Germany |
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13
09.00 am |
An unexpected role for nucleotides in anti-phage defense
Philip Kranzusch
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14
09.30 am |
cGMP-dependent Pucsar antiphage defense systems
Dinshaw Patel
Structural Biology, Memorial Sloan-Kettering Cancer Center, New York, United States
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15
09.50 am |
TIR signaling activates caspase-like immunity in bacteria
Francois Rousset
CIRI, Lyon, France
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| Coffee Break |
| 10.20 am-11.00 am (GMT+1)
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| Nucleotides and antiphage defense - Part 2 |
| 11.00 am-12.40 pm (GMT+1)
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| Chair: Kailey Slavik, The Rockefeller University, United States |
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16
11.00 am |
How to trick a sponge without really trying: a lesson in anti-anti-anti-phage immunity
Benjamin Morehouse
UC Irvine, Irvine, United States
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17
11.30 am |
An inverse immune signaling pathway that safeguards bacterial defense
Erin Doherty
Jennifer Doudna, UC Berkeley, Berkeley, United States
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18
11.50 am |
Activating and inhibiting nucleotide signals regulate Clover anti-phage defense
Sonomi YAMAGUCHI
Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, United States Department of Microbiology, Harvard Medical School, Boston, United States
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19
12.10 pm |
Cyclic Nucleotide Defence Signalling: mechanistic underpinnings of varied regulatory strategies
Malcolm White
University of St Andrews, Scotland, United Kingdom
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| Lunch and Posters Session 2 - Part 1 |
| 12.40 pm-2.30 pm (GMT+1)
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| Antiphage systems in natural isolates |
| 2.30 pm-3.50 pm (GMT+1)
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| Chair: Pedro Leão, Radboud University, The Netherlands |
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20
2.30 pm |
Phage warfare: Understanding the importance of prophage-encoded anti-phage defence inPseudomonas aeruginosa
Stineke Van Houte
Exeter University, Exeter, United Kingdom
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21
3.00 pm |
Environmental and physiological factors regulate microbial immunity
Lucas Paoli
Molecular Diversity of Microbes lab, Institut Pasteur, Paris, France School of Life Sciences, EPFL, Lausanne, Switzerland
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22
3.20 pm |
Prophage-encoded antiphage defense systems in Salmonella
Sophie Helaine
Harvard Medical School, Boston, United States
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| Coffee Break |
| 3.50 pm-4.30 pm (GMT+1)
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| Regulating antiphage defense |
| 4.30 pm-6.10 pm (GMT+1)
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| Chair: Naama Aviram, Sloan Kettering Institute, United States |
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23
4.30 pm |
Autoregulating nucleotidyltransferase toxins and phage defence
Timothy Blower
Department of Biosciences, Durham University, Stockton Road, Durham, United Kingdom New England Biolabs, 240 County Road, Ipswich, Ma, 01938, United States
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24
5.00 pm |
Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway
Kevin Corbett
University of California San Diego, La Jolla, United States
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25
5.20 pm |
Translation-dependent downregulation of Cas12a mRNA by an anti-CRISPR protein
Nicole Marino
Microbiology and Immunology, Bondy-Denomy Lab, University of California San Francisco, San Francisco, United States
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26
5.50 pm |
Multigenerational Proteolytic Inactivation of Restriction upon subtle genomic hypomethylation
Alexis Villani
University of California San Francisco, San Francisco, United States
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| Posters Session 2 - Part 2 |
| 6.10 pm-8.00 pm (GMT+1)
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Thursday, April 10, 2025
| Welcome coffee |
| 08.30 am-09.00 am (GMT+1)
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| Sensing Phage infection |
| 09.00 am-10.10 am (GMT+1)
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| Chair: Nathalie Bechon, Weizmann Institute of Science, Israel |
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27
09.00 am |
How do defense systems sense phage infection?
Michael Laub
MIT & HHMI, Boston, United States
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28
09.30 am |
A bacterial TIR-based immune system senses viral capsids to initiate defense
Cameron Roberts
Laboratory of Bacteriology, Dr. Luciano Marraffini, The Rockefeller University, New York, United States
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29
09.50 am |
Gabija targets phages that antagonize RecBCD loading
Alex Hong
Microbiology and Immunology, Bondy-Denomy Lab, UC San Francisco, San Francisco, United States
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| Coffee Break |
| 10.10 am-10.50 am (GMT+1)
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| Jumbo Phages |
| 10.50 am-12.20 pm (GMT+1)
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| Chair: Jack Bravo, Institute of Science and Technology, Austria |
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30
10.50 am |
Discovery of bacterial immune system family that specifically inhibits nucleus-forming Jumbo Phages
Yuping Li
Department of Microbiology and Immunology, University of California, San Francisco, Ca 94403, United States Biozentrum, University of Basel, Basel 4056, Switzerland
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31
11.20 am |
Single or married: analysis of Jumbo killer systemgene neighborhoods reveals new two-component and single-component defense systems
Kira Makarova
National Library of Medicine, National Institutes of Health, Maryland, United States
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32
11.50 am |
Bacterial dormancy as an antiviral defense
Alexander Harms
ETH Zürich, Switzerland, Zurich, Switzerland
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| Lunch |
| 12.20 pm-2.00 pm (GMT+1)
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| Phages resistance to bacterial immunity |
| 2.00 pm-4.30 pm (GMT+1)
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| Chair: Philip Kranzusch, Harvard Medical School, United States |
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33
2.00 pm |
Phages use distinct strategies to overcome barriers to infection at the bacterial cell surface
Michele LeRoux
WUSTL, St Louis, United States
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34
2.30 pm |
Proteome-Scale Phosphorylation by Phage T7 Kinase Suppresses Host Immune Systems
Tara Bartolec
Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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35
2.50 pm |
The NAD+ battlefield: phages and bacteria in a molecular arms race
Ilya Osterman
Weizmann Institute of Science, Rehovot, Israel
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36
3.10 pm |
Interpretable machine learning reveals a diverse arsenal of anti-defenses in bacterial viruses
Anna Lopatina
University of Wien, Wien, Austria
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37
4.00 pm |
Understanding and manipulating phage resistance to bacterial immunity
Rotem Sorek
Weizmann Institut of Science, Rehovot, Israel
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| Conference summary and poster prizes (sponsored by Eligo), announcement |
| 4.30 pm-4.45 pm (GMT+1)
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| Visits of Orsay and Gala Diner |
| 5.40 pm-10.00 pm (GMT+1)
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| After party in Paris |
| 10.00 pm-02.00 am (GMT+1)
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Friday, April 11, 2025
| Optional Excursion in Paris - Cruise on the River Seine |
| 10.00 am-3.00 pm (GMT+1)
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